Increasing Antibiotic Resistance in Kids with UTIs

Children has faced a new medical trouble that they are now resistant to some of the most common antibiotics, especially kids with Urinary Tract Infections (UTIs). These medications are being warned to be ineffective as first-line treatment in the future, a new study released. The findings show that levels of antimicrobial resistance are just as high in under-18s as in adults.

Researchers from the University of Bristol and Imperial College London made a new report published in The BMJ – The British Medical Journal – to gather and review data from 58 prior observational studies in 26 different countries. They chose researches taking a look at resistance rates in children from 0 to 17 with UTIs, particularly those caused by Escherichia coli, or E coli bacteria.

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UK’s NHS Choices considers UTIs as “a relatively common infection during childhood”. It is estimated that about 1 in 10 girls and 1 in 30 boys will have had an UTI by the time they turn 16.

The researchers discovered that there was a high prevalence of resistance in all over the world, not only limited in the U.K., among children infected with UTIs caused by E coli. The results showed that resistance was likely to be significantly higher among non-OECD (Organization for Economic Cooperation and Development) nations, or rich countries. The researchers found that certain common antibiotics are loss their efficacy in approximately half of all cases.

 “Prevalence of resistance to commonly prescribed antibiotics in primary care in children with urinary tract infections caused by E coli is high, particularly in countries outside the OECD. This could render some antibiotics ineffective as first-line treatments for urinary tract infection,” said lead researcher PhD. Ashley Bryce.

The study was able to review more than 77,000 E coli samples.

health4life-antibiotic-resistance-in-kids-with-UTIs (1)Specifically, around 80 percent of childhood UTI cases in poorer nations among the developing countries were resistant to Amoxicillin, one of the most usual prescribed primary care antibiotics. 60 percent were resistant to Co-amoxiclav (Augmentin), over 25 percent to Ciprofloxacin or Cipro, and 17 percent to Nitrofurantoin or Macrobid.

In industrialized countries, the research team found about 53 percent of pediatric UTI cases to be resistant to Amoxicillin. Nearly a quarter of young patients were resistant to the Trimethoprim, and more than 8 percent to Co-amoxiclav.

The researchers speculated there were other reasons aside from over-the-counter antibiotic use for the disparity in resistance rates between the two groups of countries. For instance, non-OECD nations likely have weaker health care infrastructure, meaning doctors and patients alike are less likely to monitor antibiotic use carefully. Similarly, infections or injuries that would be manageable elsewhere spiral out of control more often, leading to a greater use of antibiotics to prevent death.

“If left unaddressed, antibiotic resistance could re-create a world in which invasive surgeries are impossible and people routinely die from simple bacterial infections,” added the authors.

Dr. Céire Costelloe co-led the research and emphasized that “the results also suggest previous antibiotic use increased the subsequent risk of E coli resistance to that particular antibiotic – for up to 6 months after treatment.”

Prof Dame Sally Davies, the Chief Medical Officer, has warned that doctors may be unable to perform certain operations in the future if the tide is not turned.

The World Health Organization has alarmed that antimicrobial resistance could claim as many as 10 million lives a year in future decades. It has called antibiotic resistance a global health crisis since people globally said to be increasingly anxious on the role of antibiotics and the exact way to take them.

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