Active lifestyle mitigate obesity genes


According to a research published in Scientific Reports, an Active lifestyle may somehow help mitigate the risk of obesity.

 Obesity has been increasingly widespread all over the world, which provokes bad effects on our health, including psychological disturbance, osteoarthritis, cardiovascular disease, type 2 diabetes and also cancer. In addition, life expectancy of obese people is up to 8 – 13 years shorter than normal ones. Research shown that who are predisposed to genes are far more likely to get involved in obesity. The genes associated strongly with obesity is FTO (fat mass and obesity associate). Besides, excessive energy intake, which is related to sedentary life style, is a major factor contributing to obesity.


An investigation was carried out by David Meyre and his colleagues from McMaster’s Michael G. DeGroote School of Medicine, Ontario, Canada, with an aim to identify if active lifestyles could help lower the influence of genes on body weight in multiethnic populations.

Data was collected from 6 ethnic groups from 17 countries in almost all parts of the earth. The number of participants reached 17,400. 53,9%, 18,9%, 15,8%, 7,2%, 2,9% and 1,3% are the proportion of European, Latino, South Asian, African,  Native American and East Asian participants respectively. These 17,400 people were followed for more than 3 years.

To work out the connection between obesity and physical activity behaviour, the team used both basic and precise measures of physical activity as well as compared the traditional BMI with the more recently developed BAI (body adiposity index).

Moreover, David Meyre and his team analyzed the relationships between the effects of exercise and 14 obesity-related genetic traits.

Statistics from the research indicated that exercises can decrease the influence of FTO gene by up to 75%, lowering the impacts of genetic factors on BMI.

It is a reasonably biological association. FTO is nucleic acid demethylase, of which intron 1 variation links with different methylation profiles and BMI variance. As changes like physical activity and diets affect DNA methylation, it is believed that GEI and FTO have a tight connection.

It has been verified that physical activities can change mARN pattern of genes and the methylation, in muscle and fatty issue.

The results of this research, according to Meyre, gives people with obesity predisposing genes the hope of changing the situations. Also, it generates strong motivation for further investigations related to the association between lifestyle factors and obesity.



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